https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31068 Wed 24 Nov 2021 15:51:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51839 Wed 20 Sep 2023 16:12:04 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47060 Wed 13 Mar 2024 08:04:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52410 Wed 11 Oct 2023 11:59:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25338 s = 0.398, P = 0.015) and (r_s = 0.455, P = 0.005) respectively), with 1.7% greater absolute weight loss at week 10 corresponding to each one unit reduction in the asthma-related quality of life score at baseline. Furthermore, a lower baseline forced expiratory volume in 1 s/forced vital capacity correlated with greater weight loss (r_s = 0.398, P = 0.015). Male sex was associated with a 3.6 kg greater weight loss (P = 0.087). Reducing emotional eating during the programme was associated with greater weight loss in women (r_s = 0.576, P = 0.010). Conclusions This study demonstrates that individuals with more severe asthma at baseline are more successful in achieving weight loss, which could be a consequence of greater motivation and could be used as a motivational tool within the clinical setting. Gender tailoring of weight loss programmes may be useful to enhance weight loss success. Future studies are urgently needed to establish predictors of long-term weight loss maintenance in those with asthma. See Editorial, page 179 This study is the first to demonstrate that more severe asthma at baseline, male sex, and improvements in eating behaviours during weight loss are associated with greater weight loss success in overweight and obese adults with asthma. Our findings may inform the development of asthma-specific weight management guidelines.]]> Wed 11 Apr 2018 16:17:48 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12899 Wed 11 Apr 2018 15:23:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24115 Wed 11 Apr 2018 11:19:58 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19199 Wed 11 Apr 2018 10:44:57 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15547 Wed 11 Apr 2018 10:43:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29974 2) COPD patients received a 12 week weight reduction programme involving meal replacements, dietary counselling by a dietitian and resistance exercise training prescribed and supervised by a physiotherapist. Patients were reviewed face to face by the dietitian and physiotherapist every 2 weeks for counselling. Results: Twenty-eight participants completed the intervention. Mean (standard deviation) body mass index was 36.3 kg/m2 (4.6) at baseline and reduced by 2.4 kg/m2 ((1.1) P < 0.0001) after the intervention. Importantly, skeletal muscle mass was maintained. Clinical outcomes improved with weight loss including exercise capacity, health status, dyspnea, strength and functional outcomes. There was also a significant reduction in the body mass index, obstruction, dyspnea and exercise score (BODE). Systemic inflammation measured by C-reactive protein however did not change. Conclusion: In obese COPD patients, dietary energy restriction coupled with resistance exercise training results in clinically significant improvements in body mass index, exercise tolerance and health status, whilst preserving skeletal muscle mass. This novel study provides a framework for development of guidelines for the management of obese COPD patients and in guiding future research.]]> Wed 09 Mar 2022 15:59:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31201 Wed 02 Mar 2022 14:27:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44806 Wed 01 May 2024 12:05:04 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52880 Tue 31 Oct 2023 10:44:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46094 1 and FVC. Trends towards similar clinical associations with elevated MCs were observed in a paucigranulocytic subpopulation (n = 15) lacking airway eosinophilia or neutrophilia. Receiver operator characteristic (ROC) analysis showed peripheral blood eosinophil (PBE) count predicted elevated sputum eosinophils and basophils, but not MCs. Conclusions and Clinical Relevance: Sputum MCs are elevated in asthma, and their measurement may be useful as they relate to key clinical features of asthma (spirometry, asthma control, AHR). PBE count did not predict airway MC status, suggesting direct measurement of airway MCs by sensitive methods such as flow cytometry should be further developed.]]> Tue 21 May 2024 11:55:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34928 Tue 04 Jun 2019 14:03:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45375 Thu 27 Oct 2022 16:54:22 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30509 18 years) with obesity (body mass index; BMI = 30 kg/m²) and COPD, using a low-calorie diet coupled with a partial meal replacement plan and resistance exercise training, which resulted in a 6.4% reduction in weight while maintaining skeletal muscle mass and improving health status. This sub-study aims to evaluate the intervention by (a) examining changes in dietary intake and nutritional biomarkers and (b) examining predictors of weight loss. Dietary intake was evaluated using four-day food diaries, and analysis of plasma fatty acids and plasma carotenoids as biomarkers of dietary fat intake and fruit and vegetable intake, respectively. Twenty-eight obese COPD subjects (n = 17 males, n = 11 females) with a mean (standard deviation; SD) age of 67.6 (6.3) years completed the 12-week weight loss intervention. Pre-intervention, mean (SD) BMI was 36.3 (4.6) kg/m². Micronutrient intake improved from pre- to post-intervention, with the percentage of subjects meeting the Nutrient Reference Values increased for all micronutrients. Post-intervention, significant decreases in total (p = 0.009) and saturated fat intake (p = 0.037), and corresponding decreases in total (p = 0.007) and saturated plasma fatty acids (p = 0.003) were observed. There was a trend towards higher total carotenoids post-intervention (p = 0.078). Older age (p = 0.025), higher pre-intervention uncontrolled eating (p < 0.001) and plasma carotenoids (p = 0.009) predicted weight loss. This demonstrates the efficacy of a weight loss intervention in improving diet quality of obese COPD adults.]]> Thu 24 Mar 2022 11:34:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7532 Sat 24 Mar 2018 08:38:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13798 Sat 24 Mar 2018 08:25:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16941 10CRP. Sex, BMI, and %FEV₁ were significant predictors of log₁₀IL-6. Conclusions: Systemic inflammation is increased in patients with asthma with neutrophilic airway inflammation and associated with worse clinical outcomes. Systemic inflammation may contribute to the pathophysiology of neutrophilic asthma.]]> Sat 24 Mar 2018 08:05:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16937 Sat 24 Mar 2018 07:51:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26767 Sat 24 Mar 2018 07:24:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47276 Mon 27 Mar 2023 13:58:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53538 Mon 04 Dec 2023 15:44:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38021 Fri 23 Jul 2021 16:29:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55139 Fri 12 Apr 2024 18:03:16 AEST ]]>